Applied biology with the use of the zebrafish model to study human diseases. Nervous System Development: Elucidation of the molecular mechanisms leading to the proper differentiation of the vertebrate CNS system using zebrafish as a model and links with human pathologies. Muscle Development : Elucidation of the molecular mechanisms leading to the proper differentiation of the vertebrate muscle system using zebrafish as a model and links with human pathologies.
Biography
During my 10 years of scientific career I have been successfully involved in studies on different systems and organs using zebrafish as a tool to mimic human diseases. My main research interests have been the generation of zebrafish models to understand the functional role of genes mainly involved in nervous system and muscle development but I wasinvolved in several collaborative projects with senior such as Prof. Cossu, Prof Messina, Prof.Cattaneo University of Milan, Prof. Duga Humanitas University in Milan, Prof. Allende University of Chile, , Prof. Giordano Temple University, Philadelphia, USA, Prof. Bassi,Politecnico of Milan. I am leading, as Principal Investigator, a research group focusing on understanding the role of cohesins members that, when contitutively mutated, originate the Cornelia de Lange Syndrome, a genetic disease with main involvement of the developing central nervous system. Recent findings connect somatic mutations in cohesinsand leukemia insurgence. Therefore I also investigate the role of cohesins in myeloid neoplasms generating zebrafish models with deregulation of cohesin members such as nipblb, smc1a and hdac8. I have authored 20 peer-reviewed published papers; with 11 publications among them with my participation as first, last or co-corresponding author. My H-Index is 9 and the total sum of times cited is 283. In the past three years I was Assistant Professor type A in Applied BiologyDept. of Medical Biotechnology and Translational Medicine and now I have won the concur for Associate Professor type B in Applied Biology, Dept. of Medical Biotechnology and Translational Medicine.